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Griffonia (Griffonia simplicifolia) is an African shrub, in the seeds of which the active compound 5-hydroxytryptophan is found, from which serotonin is formed in the body. Typically, 5-HTP is used in the treatment of psychological disorders, mood disorders, including depression, and is considered a safe dietary supplement for adults.

But before taking any herbal remedies, the potential dangers associated with taking these dietary supplements need to be investigated. Some negative interactions with prescription drugs may occur. Serious side effects occur after using the drug in excessive dosages.

Griffonia grows in several regions of the African continent, including West and Central Africa. Historically, the leaves and crushed seeds of griffonia have been used in folk medicine for over a thousand years.

A soothing tea is brewed from the leaves, and the seeds have a relaxing effect, fight stress, and facilitate sleep and digestion.

In the West, griffonia is rarely sold in seed form. However, the active compound in seeds, 5-hydroxytryptophan, has recently become quite popular in selected dietary supplements.

In this article, you will learn:

African plant Griffonia Common

Griffonia is a shrub that grows in western and central Africa. It is acclimated to grow in conditions closer to coastal regions, but it can also be found deep in the jungle. Commonly found in Liberia, Nigeria, Gabon, and Congo.

This large shrub plant has thick and fibrous brown branches and grows up to 3 m in height. The flowers are long, cylindrical, buds appear from August to October. Griffonia produces seeds rich in the active ingredient, 5-hydroxytryptophan (5-HTP). It is a precursor to the neurotransmitter serotonin.

Raw, untreated griffonia seeds contain approximately 6-14% 5-HTP, and the leaves also contain small amounts of 5-HTP and 5-hydroxytryptamine. Both of these ingredients improve the production of serotonin in the body.

How is griffonia used in its home country and around the world?

In African countries, griffonia prostate is used as a medicine for various diseases. The chemicals in the leaves are helpful in treating coughs and act as an aphrodisiac.

The stems and leaves, combined together, are used as an antiseptic. In addition, powdered extract of Griffonia roots is suitable for treating sickle cell anemia. On the African continent, the shrub is used not only for the treatment of people, but also for domestic animals, especially chickens.

The Western world is capturing almost every possibility of herbal supplementation and Griffonia is no exception. The plant's powdery seeds, rich in 5-HTP, are processed into dietary supplements that are used to relieve conditions such as insomnia, depression, or ADHD.

The seeds come directly from African countries. The shrubs are cut, sorted, cleaned, and the seeds are extracted, which are then ground to a grayish white powder containing 95 to 98% 5-hydroxytryptophan. The most expensive powder contains 97 - 98% 5-HTP. Most of the treated seeds are purchased by the United Kingdom and the United States.

Other little-known uses for griffonia include:

The leaves are used in the production of palm wine and give the wine a bitter taste.
The juice that comes out of the cut stems can be drunk to quench your thirst.
The bark is processed and applied to syphilitic ulcers.
A decoction of the leaves is an excellent emetic, aphrodisiac, suitable for the treatment of cough.
The juice from the leaves is used as an enema, eye drops for sore eyes, and for treating kidney problems.
The paste from the leaves is applied to burns.
A decoction of stems and leaves is a laxative for the treatment of constipation and an antiseptic liquid for external use for the treatment of purulent wounds.
The stems and stem bark of the griffonia are made into a paste that is applied to decaying teeth.
Powdered bark from the branches, combined with lemon juice and pepper, is used for pain in the ribs.
Sickle cell anemia is treated with an extract of powdered roots. Linospermoside cyanoglucoside was isolated from the roots. It is an active ingredient against sickle cell disease.
The seeds are a source of 5-hydroxytryptophan, which increases CNS serotonin synthesis in humans and is effective in treating a wide range of conditions, including depression, fibromyalgia, obesity, chronic headaches, and insomnia.
The leaves contain volatile oil and coumarins.
Griffonia contains the B4 isocline and is considered a marker of small primary sensory neurons in neurological research.
The leaves are used to kill lice.
The roots are dried and ground into a white powder, which is used by women as a medicated face powder.
A black dye is obtained from the leaves.
Baskets and cages are made from the stems.
The stems are covered with fibers that serve as chewing sponges for cleaning teeth in Ghana.
The roots are also used as chewing sticks for cleaning teeth, maintaining gum health, and oral hygiene.
The seeds contain the compound 5-HTP, which is poisonous to some insects, that is, the four-spotted caryopsis (Callosobruchus maculatus).
The seeds contain lectins. One of these belongs to the acetylglucosamine group, which is commonly found in Poaceae and Solanaceae, but rarely found in Fabaceae. Some lectins are insecticidal.
The stems are quite tough, and canes are made of them.

How is griffonia processed in the body?

5-Hydroxytryptophan from Griffonia Prostolia Extract is used by the body in the same way as regular 5-HTP, which is produced in the body on its own.

5-Hydroxytryptophan is formed in the body, starting with the breakdown of the amino acid tryptophan. Tryptophan is found in many high protein food sources, including poultry, eggs, red meat, milk, spinach, beans, lentils, and nuts.

For better assimilation of tryptophan, it is necessary to consume carbohydrates, because under the condition of an unbalanced diet, the amino acid enters the body quite little. 90 - 95% of tryptophan is metabolized to other compounds, and only 5 - 10% to 5-hydroxytryptophan.

5-HTP travels through the bloodstream to the brain, crosses the blood-brain barrier, and enters the brain. Then, in the brain, 5-HTP is converted into the neurotransmitter serotonin.

Serotonin is a major neurochemical that is associated with mood enhancement. In particular, it accompanies feelings of calm and relaxation, and can cause feelings of joy or even intense euphoria.

With stress, anxiety, emotional disorders, serotonin deficiency occurs, since most of the tryptophan is metabolized into other compounds and even less enters the body with an unbalanced intake of proteins and carbohydrates. Under these conditions, tryptophan is not available for the biosynthesis of serotonin, but there are no such problems for 5-hydroxytryptophan.

Unlike tryptophan, 5-HTP does not need to be consumed at the same time in the brain and is metabolized into serotonin alone. It is better to use nutritional supplements of natural origin obtained by extraction from the seeds of the African shrub Griffonia.

Some illegal drugs, like MDMA, work by stimulating massive, unnatural releases of serotonin. These drugs are dangerous not only to health, but also to life.

The effects of conventional 5-HTP supplements are milder because they create moderate levels of serotonin. If you have a poor diet or poor genetic makeup, you can take gryphonia supplements or other plant sources of 5-hydroxytryptophan.

Positive Effects of Griffonia Supplements

Griffonia vulgaris is a food that may also have a positive effect on dopamine levels in the brain.Many stimulants increase dopamine to generate short-term improvements in mental focus.

However, this approach is sometimes difficult to sustain. For people who have difficulty managing chaotic psychic energy, this type of therapy is too intense.

On the other hand, 5-HTP limits the excessive increase in dopamine and creates a balance with serotonin. The result is a sense of mental and emotional control through calm, relaxing feelings, as opposed to a high burst of energy.

For these reasons, 5-hydroxytryptophan supplements are sometimes prescribed as a natural alternative to medication for people with depression and anxiety.

Some people use griffonia seeds for migraine pain and fibromyalgia. They have been shown in studies to improve symptoms of fibromyalgia, including pain severity, morning stiffness, and insomnia.

Gryphonia seed extract can control impulsivity, which is why some people use it for ADHD. All of these benefits are undeniably associated with increased serotonin levels.

Another important reason for taking griffonia supplements is that 5-HTP can be effective in suppressing appetite and thus weight loss in obese patients. High serotonin levels make you feel full, so you don't want to eat excessive amounts of food.

As stated, these supplements limit the synthesis of dopamine, a neurotransmitter that increases appetite. This dual method of action significantly suppresses hunger so you are more likely to stick to a healthy diet plan.

Hidden dangers and side effects

Griffonia in the form of dietary supplements has been evaluated as a safe oral agent for use in adults. But for pregnant and breastfeeding women, children and people with Down syndrome it is not safe to use such drugs, they should avoid them.

For most people, griffonia does not cause adverse or allergic reactions. In traditional forms of use like tea, the seeds of the plant produce a mild mood boost without any side effects.

5-HTP powders and tablets as standalone supplements are equally safe and mild in most people. Some patients report minor gastrointestinal adverse reactions, including nausea, heartburn, vomiting, and diarrhea.

If these supplements are taken in extremely high doses or in combination with other drugs to alter serotonin levels (such as antidepressants), a condition called serotonin syndrome can develop. It occurs when there is an excess amount of serotonin in the brain.

Side effects include headaches, sweating, difficulty concentrating, and an irregular heartbeat. In extreme cases, if left untreated, then this syndrome can become fatal for a person.

Griffonia can cause drowsiness. It should not be used with other herbs with similar effects: California poppy, catnip, hops, Jamaican dogwood, kava, St. John's wort, valerian, and others.

Therefore, always adhere to the recommended dosages to achieve not only the best treatment results, but also safe for your health.

What is the correct dosage?

The correct dosage of herbal griffonia supplements depends on many factors, including age, weight, physiology, individual sensitivity, and the reason for taking the supplement.

The recommendations below are only general guidelines. Before using any new medications, talk to your doctor first to determine the optimal dosage based on your personal needs.

The ideal dosage for 5-HTP from Griffonia for most people is a maximum of 100 mg per day.This is the standard dosage you can read on most commercial drug product labels.

50 mg daily is a good starting dose for first-timers. This dosage has a mild yet noticeable effect on many people.

Many griffonia tablets are mixed with other ingredients like melatonin, tyrosine, GABA, or St. John's wort. You can buy one Griffonia simplicifolia first to test its effect independently of the other ingredients in the combination formulation.

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